TOSC: an algorithm for the tomography of spotted transit chords

Photometric observations of planetary transits may show localized bumps, called transit anomalies, due to the possible crossing of photospheric starspots. The aim of this work is to analyze the transit anomalies and derive the temperature profile inside the transit belt along the transit direction. We develop the algorithm TOSC, a tomographic inverse-approach tool which, by means of simple algebra, reconstructs the flux distribution along the transit belt. We test TOSC against some simulated scenarios. We find that TOSC provides robust results for light curves with photometric accuracies better than 1~mmag, returning the spot-photosphere temperature contrast with an accuracy better than 100~K. TOSC is also robust against the presence of unocculted spots, provided that the apparent planetary radius given by the fit of the transit light curve is used in place of the true radius. The analysis of real data with TOSC returns results consistent with previous studies

HAZMAT VI: The Evolution of Extreme Ultraviolet Radiation Emitted from Early M Star

Quantifying the evolution of stellar extreme ultraviolet (EUV, 100 -- 1000 $\overset{\circ}{A}$) emission is critical for assessing the evolution of planetary atmospheres and the habitability of M dwarf systems. Previous studies from the HAbitable Zones and M dwarf Activity across Time (HAZMAT) program showed the far- and near-UV (FUV, NUV) emission from M stars at various stages of a stellar lifetime through photometric measurements from the Galaxy Evolution Explorer (GALEX). The results revealed increased levels of short-wavelength emission that remain elevated for hundreds of millions of years. The trend for EUV flux as a function of age could not be determined empirically because absorption by the interstellar medium prevents access to the EUV wavelengths for the vast majority of stars. In this paper, we model the evolution of EUV flux from early M stars to address this observational gap. We present synthetic spectra spanning EUV to infrared wavelengths of 0.4 $\pm$ 0.05 M$_{\odot}$ stars at five distinct ages between 10 and 5000 Myr, computed with the PHOENIX atmosphere code and guided by the GALEX photometry. We model a range of EUV fluxes spanning two orders of magnitude, consistent with the observed spread in X-ray, FUV, and NUV flux at each epoch. Our results show that the stellar EUV emission from young M stars is 100 times stronger than field age M stars, and decreases as t$^{-1}$ after remaining constant for a few hundred million years. This decline stems from changes in the chromospheric temperature structure, which steadily shifts outward with time. Our models reconstruct the full spectrally and temporally resolved history of an M star's UV radiation, including the unobservable EUV radiation, which drives planetary atmospheric escape, directly impacting a planet's potential for habitability.Comment: 23 pages, 15 figures, accepted to Ap

The contribution of the major planet search surveys to EChO target selection

The EChO core science will be based on a three tier survey, each with increasing sensitivity, in order to study the population of exo-planets from super-Earths to Jupiter-like planets, in the very hot to temperate zones (temperatures of 300 K - 3000 K) of F to M-type host stars. To achieve a meaningful outcome an accurate selection of the target sample is needed. In this paper we analyse the targets, suitable for EChO observations, expected to result from a sample of present and forthcoming detection surveys. Exoplanets currently known are already sufficient to provide a large and diverse sample. However we expect the results from these surveys to increase the sample of smaller planets that will allow us to optimize the EChO sample selection.Comment: Submitted to Experimental Astronom

The triple system AT Mic AB + AU Mic in the β Pictoris association

Equal-mass stars in young open clusters and loose associations exhibit a wide spread of rotation periods, which likely originates from differences in the initial rotation periods and in the primordial disc lifetimes. We want to explore if the gravitational effects by nearby companions may play an additional role in producing the observed rotation period spread, as well as, the role that magnetic activity may also play. We measure the photometric rotation periods of components of multiple stellar systems and look for correlations of the period differences among the components to their reciprocal distances. In this paper, we analyzed the triple system AU Mic + AT Mic A&B in the 25± 3-Myr β Pictoris association. We have retrieved from the literature the rotation period of AU Mic ({P} = 4.85 d) and measured from photometric archival data the rotation periods of both components of AT Mic ({P} = 1.19 d and {P} = 0.78 d) for the first time. Moreover, we detected a high rate of flare events from AT Mic. Whereas the distant component AU Mic has evolved rotationally as a single star, the A and B components of AT Mic, separated by ∼ 27 AU, exhibit a rotation rate a factor 5 larger than AU Mic. Moreover, the A and B components, despite have about equal mass, show a significant difference (∼ 40 %) between their rotation periods. A possible explanation is that the gravitational forces between the A and B components of AT Mic (that are a factor ∼ 7.3× 106 more intense than those between AU Mic and AT Mic) have enhanced the dispersal of the AT Mic primordial disc, shortening its lifetime and the disc-locking phase duration, making the component A and B of AT Mic to rotate faster than the more distant AU Mic. We suspect that a different level of magnetic activity between the A and B components of AT Mic may be the additional parameter responsible for the difference between their rotation periods

Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literature.

A systematic review was performed to evaluate the biological effects of Cannabidiol (CBD), one of the major components of Cannabis Sativa, on normal human healthy cell populations in terms of cell viability, proliferation, migration, apoptosis and inflammation. Inclusion criteria were: studies on cell lines and primary cell culture from healthy donors, CBD exposure as variable, no CBD exposure as control and published in English language. Quality assessment was based on ToxR tool, with a score of reliability ranging from 15 to 18.Following the PRISMA statement, three independent reviewers performed both a manual and an electronic search using MEDLINE via PubMed, Scopus, Web of Science and Cochrane. From a total of 9437eligible articles, 29 studies have been selected. The average quality assessment score was 16.48.Theresults showed heterogeneous CBD concentration exposure (0.01-50 μM or 0.1 nmol/mL-15 mg/mL). The definition of a threshold limit would allow the identification of specific effects on expected outcomes. From the data obtained CBD resulted to inhibit cell viability in a dose-dependent manner above 2 μM, while in oral cell populations the inhibitory concentration is higher than 10 μM. Moreover, it was observed a significantly inhibition of cell migration and proliferation. On the contrary, it was highlighted a stimulation of apoptosis only at high doses (from 10 μM).Finally, CBD produced an anti-inflammatory effect, with a reduction of the pro-inflammatory cytokine gene expression and secretion. CBD down-regulated ROS production, although at high concentrations (16 μM) increased ROS-related genes expression. The diffusion of CBD for therapeutic and recreational uses require a precise definition of its potential biological effects. A thorough knowledge of these aspects would allow a safe use of this substance without any possible side effects

Selective Interaction of Colistin with Lipid Model Membranes

Although colistin's clinical use is limited due to its nephrotoxicity, colistin is considered to be an antibiotic of last resort because it is used to treat patients infected with multidrug-resistant bacteria. In an effort to provide molecular details about colistin's ability to kill Gram-negative (G(−)) but not Gram-positive (G(+)) bacteria, we investigated the biophysics of the interaction between colistin and lipid mixtures mimicking the cytoplasmic membrane of G(+), G(−) bacteria as well as eukaryotic cells. Two different models of the G(−) outer membrane (OM) were assayed: lipid A with two deoxy-manno-octulosonyl sugar residues, and Escherichia coli lipopolysaccharide mixed with dilaurylphosphatidylglycerol. We used circular dichroism and x-ray diffuse scattering at low and wide angle in stacked multilayered samples, and neutron reflectivity of single, tethered bilayers mixed with colistin. We found no differences in secondary structure when colistin was bound to G(−) versus G(+) membrane mimics, ruling out a protein conformational change as the cause of this difference. However, bending modulus KC perturbation was quite irregular for the G(−) inner membrane, where colistin produced a softening of the membranes at an intermediate lipid/peptide molar ratio but stiffening at lower and higher peptide concentrations, whereas in G(+) and eukaryotic mimics there was only a slight softening. Acyl chain order in G(−) was perturbed similarly to KC. In G(+), there was only a slight softening and disordering effect, whereas in OM mimics, there was a slight stiffening and ordering of both membranes with increasing colistin. X-ray and neutron reflectivity structural results reveal colistin partitions deepest to reach the hydrocarbon interior in G(−) membranes, but remains in the headgroup region in G(+), OM, and eukaryotic mimics. It is possible that domain formation is responsible for the erratic response of G(−) inner membranes to colistin and for its deeper penetration, which could increase membrane permeability.Fil: Dupuy, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. University of Carnegie Mellon; Estados UnidosFil: Pagano, Isabella. University of Carnegie Mellon; Estados UnidosFil: Andenoro, Kathryn. University of Carnegie Mellon; Estados UnidosFil: Peralta, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. University of Carnegie Mellon; Estados UnidosFil: Elhady, Yasmene. University of Carnegie Mellon; Estados UnidosFil: Heinrich, Frank. University of Carnegie Mellon; Estados UnidosFil: Tristram-nagle, Stephanie. University of Carnegie Mellon; Estados Unido

On-sky single-mode fiber coupling measurements at the Large Binocular Telescope

The demonstration of efficient single-mode fiber (SMF) coupling is a key requirement for the development of a compact, ultra-precise radial velocity (RV) spectrograph. iLocater is a next generation instrument for the Large Binocular Telescope (LBT) that uses adaptive optics (AO) to inject starlight into a SMF. In preparation for commissioning iLocater, a prototype SMF injection system was installed and tested at the LBT in the Y-band (0.970-1.065 $\mu$m). This system was designed to verify the capability of the LBT AO system as well as characterize on-sky SMF coupling efficiencies. SMF coupling was measured on stars with variable airmasses, apparent magnitudes, and seeing conditions for six half-nights using the Large Binocular Telescope Interferometer. We present the overall optical and mechanical performance of the SMF injection system, including details of the installation and alignment procedure. A particular emphasis is placed on analyzing the instrument's performance as a function of telescope elevation to inform the final design of the fiber injection system for iLocater.Comment: 11 pages, 7 figure